Cissus quadrangularis has been used in traditional Eastern medicine for hundreds of years. Cissus quadrangularis is loaded with antioxidants, ascorbic acid, calcium, carotene/carotenoids, resveratrol and triterpinoids.
I truly believe this is an extremely undervalued ingredient when it comes to joint and collagen supplementation. We used a whopping 750mg per serving!
Source: Cissus quadrangularis inhibits IL-1β induced inflammatory responses on chondrocytes and alleviates bone deterioration in osteotomized rats via p38 MAPK signaling. 5 June 2015.vol 2015:9 p 2927-2940
Palmitoylethanolamide (PEA, a mouthful) is your body’s main naturally produced. PEA is one of many fatty acids that have the enthanolamide functional group attached to it. Its origins go back to an obscure study in the 1940s showing that PEA derived from purified egg yolks.
In 1964, it was first isolated in mammalian tissues and has over 350 studies since. PEA binds to the nuclear receptor, where it then elicits a variety of biological activities.
Curcumin is one of the main curcuminoids found in turmeric. There have been hundreds of studies on curcumin and its positive effects on overall health. NVP helps encase and disperse the curcuminoids to help them be more hydrophilic(water soluble). This allows your body to utilize much more of the active curcuminoids.
The gum resin from Boswellia serrata has been used for centuries because its rich in terpene and triterpenic acids, known as boswellic acids. The most potent of them being 11-keto--boswellic acid and 3-O-acetly-11-keto--boswellic acid(AKBA). Studies show that taking 1 serving of AprèsFlex begins to work in as little as 5 days! No more taking big chalky pills for 30days to help.
Undenatured type-II collagen or UC-II has been extensively studies in humans. The key term here is UNDENATURED. This means the protein of the collagen is exactly has it is inside the body and includes all the necessary components like proteoglycans, glucosamine hyaluronic acid, and chondroitin sulfate.
These make up the very basics of cartiliage and synovial fluid- the viscous, non-Newtonian fluid between your joints.
We have already spoken about curcumin and its many benefits, we all as pitfalls. One major pitfall we spoke about was oral bioavailability, which I rectified using an highly-bioavailable form known as CurcuWin. However, we have yet to speak about one of the main metabolites of curcumin known as tetrahydrocurucmin.
The “tetrahydro” means that there is a reduction in 2 double bonds on the molecule where 4 hydrogens are added in place. This dramatically improves the oral bioavailability of curcumin, especially in the intestinal tract.
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2. Jadhav, Atul N., et al. "Ketosteroid standardized Cissus quadrangularis L. extract and its anabolic activity: Time to look beyond ketosteroid?." Pharmacognosy magazine 12.Suppl 2 (2016): S213.
3. Ghouse, Mr Mohammed Shakir. "A pharmacognostical review on cissus quadrangularis linn." International Journal of Research 28 (2015).
4. Oben, Julius E., et al. "The effect of Cissus quadrangularis (CQR-300) and a Cissus formulation (CORE) on obesity and obesity-induced oxidative stress." Lipids in Health and Disease 6.1 (2007): 1-8.
5. Solorzano, Carlos, et al. "Selective N-acylethanolamine-hydrolyzing acid amidase inhibition reveals a key role for endogenous palmitoylethanolamide in inflammation." Proceedings of the National Academy of Sciences 106.49 (2009): 20966-20971.
6. Artukoglu, Bekir Berker, et al. "Efficacy of palmitoylethanolamide for pain: a meta-analysis." Pain Physician 20.5 (2017): 353-362.
7. M Keppel Hesselink, Jan. "New targets in pain, non-neuronal cells, and the role of palmitoylethanolamide." The Open Pain Journal 5.1 (2012).
8. Gabrielsson, Linda, Sofia Mattsson, and Christopher J. Fowler. "Palmitoylethanolamide for the treatment of pain: pharmacokinetics, safety and efficacy." British journal of clinical pharmacology 82.4 (2016): 932-942.
9. Sundaram, Mahalingam S., et al. "Tamarind seed (Tamarindus indica) extract ameliorates adjuvant-induced arthritis via regulating the mediators of cartilage/bone degeneration, inflammation and oxidative stress." Scientific reports 5.1 (2015): 1-13.
10. Oliver, Jonathan Michael, et al. "Novel form of curcumin attenuates performance decrements following muscle damaging exercise." The FASEB Journal 31 (2017): lb415-lb415.
11. Juturu, Vijaya, et al. "Antioxidant Properties and Safety Evaluation of Curcumin (CurcuWINTM)." The FASEB Journal 29 (2015): 924-5.
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13. Kanwar, Jagat R., et al. "Cissus quadrangularis inhibits IL-1β induced inflammatory responses on chondrocytes and alleviates bone deterioration in osteotomized rats via p38 MAPK signaling." Drug design, development and therapy 9 (2015): 2927.
14. Lugo, James P., et al. "Undenatured type II collagen (UC-II®) for joint support: a randomized, double-blind, placebo-controlled study in healthy volunteers." Journal of the International Society of Sports Nutrition 10.1 (2013): 1-12.
15. Crowley, David C., et al. "Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial." International journal of medical sciences 6.6 (2009): 312.
16. Bagchi, D., et al. "Effects of orally administered undenatured type II collagen against arthritic inflammatory diseases: a mechanistic exploration." International journal of clinical pharmacology research 22.3-4 (2002): 101-110.
17. Aggarwal, Bharat B et al; “Curcumin differs from tetrahydrocurcumin for molecular targets, signaling pathways and cellular responses.”; Molecules (Basel, Switzerland); vol. 20,1; 185-205; 24 Dec. 2014;
18. Sandur, Santosh K., et al. "Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism." Carcinogenesis 28.8 (2007): 1765-1773.
19. Sugiyama, Yosunori, Shunro Kawakishi, and Toshihiko Osawa. "Involvement of the β-diketone moiety in the antioxidative mechanism of tetrahydrocurcumin." Biochemical pharmacology 52.4 (1996): 519-525.
20. Zhang, Zhen-Biao, et al. "Curcumin’s metabolites, tetrahydrocurcumin and octahydrocurcumin, possess superior anti-inflammatory effects in vivo through suppression of TAK1-NF-κB pathway." Frontiers in pharmacology 9 (2018): 1181.
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